Aryl Hydrocarbon Receptor (AhR) Antibody
273€ (100 µl)
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935106861
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name
Aryl Hydrocarbon Receptor (AhR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx102411
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Aryl Hydrocarbon Receptor (AhR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aryl Hydrocarbon Receptor (AhR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35869 |
| Alias | RP85,bHLHe76 |
| Background | Antibody anti-AHR |
| Status | RUO |
Descripción
AHR is a ligand-activated transcription factor involved in sensing and responding to environmental toxins, such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Upon ligand binding, AHR translocates from the cytoplasm to the nucleus, where it forms a heterodimer with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and binds to DNA at xenobiotic response elements (XREs), regulating the expression of detoxification enzymes like CYP1A1 and CYP1B1. AHR is expressed in a variety of tissues, including the liver, skin, and immune system, and plays roles in xenobiotic metabolism, immune regulation, cell differentiation, and circadian rhythm modulation. Dysregulation of AHR activity is implicated in immune dysfunction, autoimmune diseases, and cancer, where it influences tumor progression and metastasis. AHR’s dual role in both normal homeostasis and pathological conditions makes it a target of interest in toxicology, immunology, and cancer research.
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AHR antibody
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes(such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
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