Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 9 (AGAP9) Antibody

Background

AGAP9 is a member of the AGAP family, containing characteristic GTPase-activating protein (GAP) domains, ankyrin repeats, and a pleckstrin homology (PH) domain that enable it to regulate Arf GTPases. It is involved in intracellular vesicular trafficking, cytoskeletal reorganization, and membrane dynamics. AGAP9 modulates the activity of small GTPases, which are crucial for endosomal transport, vesicle formation, and cell migration. It is expressed in various tissues, with functional roles in signal transduction and cellular transport mechanisms. Dysregulation of AGAP9 has been implicated in diseases involving defects in intracellular trafficking and cell motility, such as cancer. Its exact mechanisms and clinical implications remain areas of active research.