Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain Containing Protein 1 (ACAP1) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain Containing Protein 1 (ACAP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx111043
tested applications
ELISA, WB
Description
Arfgap With Coiled-Coil, Ankyrin Repeat And Ph Domains 1 Antibody is a Rabbit Polyclonal antibody against Arfgap With Coiled-Coil, Ankyrin Repeat And Ph Domains 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain Containing Protein 1 (ACAP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15027 |
| Gene ID | 9744 |
| OMIM | 607763 |
| Alias | CENTB1,Centaurin beta 1 |
| Background | Antibody anti-ACAP1 |
| Status | RUO |
Descripción
ACAP1 is a multifunctional protein that acts as a GTPase-activating protein (GAP) for ADP-ribosylation factors (Arfs), small GTP-binding proteins involved in vesicle trafficking and membrane dynamics. It contains a pleckstrin homology (PH) domain, ankyrin repeats, and a coiled-coil region, enabling interactions with phospholipids and proteins. ACAP1 is involved in clathrin-mediated endocytosis and recycling of membrane proteins like integrins and nutrient receptors, regulating cellular adhesion, migration, and nutrient uptake. It plays a significant role in immune and migrating cells by recycling surface proteins critical for cellular responses. Dysregulation of ACAP1 has been linked to impaired membrane trafficking, contributing to diseases such as cancer and immune disorders.
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