Apoptosis-Inducing Factor-Like Protein (AIFL) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
Apoptosis-Inducing Factor-Like Protein (AIFL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375052
tested applications
ELISA, WB, IHC, IF/ICC
Description
Apoptosis-Inducing Factor-Like Protein (AIFL) Antibody is a Rabbit Polyclonal antibody against Apoptosis-Inducing Factor-Like Protein (AIFL).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apoptosis-Inducing Factor-Like Protein (AIFL) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96NN9 |
| Gene ID | 150209 |
| Alias | AIFM3, AIFL |
| Background | Antibody anti-AIFM3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) is a mitochondrial protein belonging to the apoptosis-inducing factor family, which is involved in regulating programmed cell death and maintaining cellular homeostasis. Unlike AIFM1, which translocates to the nucleus during apoptosis to induce DNA fragmentation, AIFM3 is primarily localized within the mitochondria and functions to maintain mitochondrial integrity and energy metabolism. It plays a role in redox homeostasis and may act as a safeguard against oxidative stress by modulating mitochondrial reactive oxygen species (ROS) production. Dysregulation of AIFM3 has been implicated in cancer, where altered apoptotic signaling contributes to tumor survival and chemoresistance. Emerging studies suggest that AIFM3 may also participate in non-apoptotic pathways, such as cellular differentiation and response to metabolic stress, making it a potential target for therapeutic intervention in mitochondrial dysfunction-related diseases and cancer.
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