Apoptosis-Inducing Factor 3 (AIFM3) Antibody
273€ (200 µl)
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935106861
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name
Apoptosis-Inducing Factor 3 (AIFM3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432153
tested applications
P-ELISA
Description
AIFM3 Antibody is a Goat Polyclonal antibody against AIFM3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apoptosis-Inducing Factor 3 (AIFM3) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 150209, 72168, 303786 |
| NCBI Accession | NP_653305.1, NP_001018070.1, NP_001139760.1 |
| Alias | AIFM3, AIFL |
| Background | Antibody anti-AIFM3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) is a mitochondrial protein belonging to the apoptosis-inducing factor family, which is involved in regulating programmed cell death and maintaining cellular homeostasis. Unlike AIFM1, which translocates to the nucleus during apoptosis to induce DNA fragmentation, AIFM3 is primarily localized within the mitochondria and functions to maintain mitochondrial integrity and energy metabolism. It plays a role in redox homeostasis and may act as a safeguard against oxidative stress by modulating mitochondrial reactive oxygen species (ROS) production. Dysregulation of AIFM3 has been implicated in cancer, where altered apoptotic signaling contributes to tumor survival and chemoresistance. Emerging studies suggest that AIFM3 may also participate in non-apoptotic pathways, such as cellular differentiation and response to metabolic stress, making it a potential target for therapeutic intervention in mitochondrial dysfunction-related diseases and cancer.
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