Apoptosis-Inducing Factor 3 (AIFM3) Antibody
221€ (50 µg)
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Name
Apoptosis-Inducing Factor 3 (AIFM3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx326199
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
AIFM3 Antibody is a Rabbit Polyclonal against AIFM3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis-Inducing Factor 3 (AIFM3) Immunogen: Synthesized peptide derived from the N-terminal region of human AIFL. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96NN9 |
| Gene ID | 150209 |
| Alias | AIFM3, AIFL |
| Background | Antibody anti-AIFM3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) is a mitochondrial protein belonging to the apoptosis-inducing factor family, which is involved in regulating programmed cell death and maintaining cellular homeostasis. Unlike AIFM1, which translocates to the nucleus during apoptosis to induce DNA fragmentation, AIFM3 is primarily localized within the mitochondria and functions to maintain mitochondrial integrity and energy metabolism. It plays a role in redox homeostasis and may act as a safeguard against oxidative stress by modulating mitochondrial reactive oxygen species (ROS) production. Dysregulation of AIFM3 has been implicated in cancer, where altered apoptotic signaling contributes to tumor survival and chemoresistance. Emerging studies suggest that AIFM3 may also participate in non-apoptotic pathways, such as cellular differentiation and response to metabolic stress, making it a potential target for therapeutic intervention in mitochondrial dysfunction-related diseases and cancer.
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