Apoptosis-inducing factor 1, mitochondrial (AIFM1) Antibody
299€ (50 µl)
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Name
Apoptosis-inducing factor 1, mitochondrial (AIFM1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402239
Tested Applications
ELISA, WB, IHC
Description
Apoptosis-inducing factor 1, mitochondrial (AIFM1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human, Rat AIFM1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis-inducing factor 1, mitochondrial (AIFM1) Immunogen: A synthesized peptide derived from human AIF |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95831 |
| Alias | AIFM1,AIF,CMT2D,CMTX4,COWCK |
| Background | Antibody anti-AIFM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
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