Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137552
Description
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody is a Mouse Monoclonal antibody against Apoptosis Inducing Factor 1, Mitochondrial (AIFM1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | AIFM1,AIF,CMT2D,CMTX4,COWCK |
| Background | Antibody anti-AIFM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
Productos relacionados
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
AIFM1 Antibody is a Rabbit Polyclonal antibody against AIFM1. This gene encodes a flavoprotein essential for nuclear dis…
Ver producto
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermem…
Ver producto Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
Rabbit Polyclonal against the AIFM1 protein.…
Ver producto