Apolipoprotein M (APOM) Antibody
169€ (20 µl)
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935106861
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name
Apolipoprotein M (APOM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322357
tested applications
ELISA, WB, IHC
Description
APOM Antibody is a Rabbit Polyclonal against APOM.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein M (APOM) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95445 |
| Gene ID | 55937 |
| NCBI Accession | NP_001243098.1, NM_001256169.1, NP_061974.2, NM_019101.2 |
| OMIM | 606907 |
| Alias | APOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M |
| Background | Antibody anti-APOM |
| Status | RUO |
| Note | Concentration: 0.58 mg/ml - |
Descripción
Apolipoprotein M (APOM) is a member of the apolipoprotein family primarily involved in lipid transport and metabolism. APOM is predominantly expressed in the liver and kidneys and is secreted into the plasma, where it associates mainly with high-density lipoprotein (HDL) particles. APOM plays a key role in lipid homeostasis by transporting sphingosine-1-phosphate (S1P), a bioactive lipid mediator involved in immune response, vascular development, and endothelial barrier integrity. APOM also enhances the anti-inflammatory and antioxidant properties of HDL, contributing to its atheroprotective function in cardiovascular health. Recent studies suggest that APOM regulates the S1P signaling pathway, which is crucial for lymphocyte trafficking, vascular permeability, and cell survival. Altered APOM levels have been observed in metabolic disorders such as type 2 diabetes, atherosclerosis, and cardiovascular disease, highlighting its role as a biomarker and potential therapeutic target. Its involvement in the modulation of endothelial function, cholesterol efflux, and immune regulation underscores APOM's critical role in maintaining cardiovascular and metabolic homeostasis. Ongoing research aims to explore APOM’s therapeutic potential, particularly in improving HDL functionality and S1P-based signaling for cardiovascular disease prevention.
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