Apolipoprotein A4 (APOA4) Antibody
383.5€ (100 µl)
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Name
Apolipoprotein A4 (APOA4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015720
Tested Applications
ELISA, WB
Description
APOA4: apolipoprotein A4.Apoliprotein (apo) A4 gene contains 3 exons separated by two introns.A sequence polymorphism has been identified in the 3'UTR of the third exon.The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles.Although its precise function is not known, apo A4 is a potent activator of lecithin-cholesterol acyltransferase in vitro.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apolipoprotein A4 (APOA4) Immunogen: Purified recombinant fragment of APOA4 (aa21-396) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06727 |
| Gene ID | 337 |
| OMIM | 107690 |
| Alias | APOA4, apolipoprotein A4, APO A4,APO A-4,apoA-IV,apoAIV,apoA4,Apolipoprotein A-IV |
| Background | Antibody anti-APOA4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
APOA4 is a protein primarily synthesized in the small intestine and secreted into the bloodstream as a component of chylomicrons during dietary fat absorption. It plays a key role in lipid metabolism, facilitating the transport and metabolism of triglycerides and cholesterol. APOA4 has been shown to activate lecithin-cholesterol acyltransferase (LCAT), promoting cholesterol esterification and contributing to reverse cholesterol transport. Additionally, APOA4 exhibits anti-inflammatory and antioxidant properties, protecting against atherosclerosis and cardiovascular diseases. It also regulates satiety by interacting with receptors in the hypothalamus, contributing to appetite control and energy balance. Elevated APOA4 levels are associated with improved lipid profiles, while its deficiency can impair lipid transport and metabolism.
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