ZFYVE19 antibody
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Description
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4(VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | zinc finger, FYVE domain containing 19 (ZFYVE19) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:10000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 52 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96K21 |
| Gene ID | 84936 |
| Alias | Abscission/NoCut checkpoint regulator (ANCHR),MLL partner containing FYVE domain,Zinc finger FYVE domain-containing protein 19,ZFYVE19,ANCHR,MPFYVE |
| Background | Antibody anti-ZFYVE19 |
| Status | RUO |
| Note | Mol. Weight 52 kDa |
Descripción
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ZFYVE19 antibody
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