ZC3HC1 antibody
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Description
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1(CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | zinc finger, C3HC-type containing 1 (ZC3HC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86WB0 |
| Gene ID | 51530 |
| Alias | Zinc finger C3HC-type protein 1,Nuclear-interacting partner of ALK (hNIPA),Nuclear-interacting partner of anaplastic lymphoma kinase,ZC3HC1,NIPA |
| Background | Antibody anti-ZC3HC1 |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
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