anti- ZC3HC1 antibody

Descripción

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1(CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

zinc finger, C3HC-type containing 1

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB

observerd MW

55 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ZC3HC1

alias

ZC3HC1, 1110054L24Rik, hNIPA, HSPC216, NIPA

uniprot id

https://www.uniprot.org/uniprotkb/Q86WB0

gene id

https://www.ncbi.nlm.nih.gov/gene/51530

note

This product is for research use only.

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