ZBP1 antibody
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Description
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor(IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Z-DNA binding protein 1 (ZBP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 66 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H171 |
| Gene ID | 81030 |
| Alias | Z-DNA-binding protein 1,DNA-dependent activator of IFN-regulatory factors (DAI),Tumor stroma and activated macrophage protein DLM-1,ZBP1,C20orf183,DLM1 |
| Background | Antibody anti-ZBP1 |
| Status | RUO |
| Note | Mol. Weight 66 kDa |
Descripción
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