ZBP1 antibody
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935106861
info@markelab.com
name
ZBP1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09586
tested applications
ELISA, WB, IHC
Description
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor(IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Z-DNA binding protein 1 (ZBP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 66 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H171 |
| Gene ID | 81030 |
| Alias | Z-DNA-binding protein 1,DNA-dependent activator of IFN-regulatory factors (DAI),Tumor stroma and activated macrophage protein DLM-1,ZBP1,C20orf183,DLM1 |
| Background | Antibody anti-ZBP1 |
| Status | RUO |
| Note | Mol. Weight 66 kDa |
Descripción
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