ERCC5 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair(NER). It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | excision repair cross-complementing rodent repair deficiency, complementation group 5 (ERCC5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:2000; IF: 1:20-1:200; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 200 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P28715 |
| Alias | DNA excision repair protein ERCC-5,DNA repair protein complementing XP-G cells,Xeroderma pigmentosum group G-complementing protein,ERCC5,ERCM2,XPG,XPGC |
| Background | Antibody anti-ERCC5 |
| Status | RUO |
| Note | Mol. Weight 200 kDa |
Descripción
Related Products
ERCC5 antibody
The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair(NER). It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].
Ver Producto
DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody
ERCC5 Antibody is a Rabbit Polyclonal antibody against ERCC5. This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].
Ver Producto
DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody
Rabbit polyclonal antibody against ERCC5 protein. Immunogen region is N-terminal.
Ver Producto