VEGFA antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
VEGFA antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab09391
Tested Applications
ELISA, IHC, IF, WB
Description
VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | vascular endothelial growth factor A (VEGFA) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 15-27kDa, 34-45kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IF, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P15692 |
| Gene ID | 7422 |
| Alias | L-VEGF,MVCD1,VEGF,VPF,Vascular permeability factor |
| Background | Antibody anti-VEGFA |
| Status | RUO |
| Note | Mol. Weight 15-27 kDa, 34-45 kDa |
Background
VEGFA is a key member of the vascular endothelial growth factor (VEGF) family and plays a crucial role in angiogenesis, vascular permeability, and endothelial cell proliferation VEGFA binds primarily to its receptors VEGFR-1 and VEGFR-2, triggering signaling pathways like PI3K/AKT and ERK/MAPK to promote blood vessel formation during embryonic development, wound healing, and tissue repair Dysregulated VEGFA expression is associated with pathological angiogenesis observed in cancer, diabetic retinopathy, and age-related macular degeneration (AMD) VEGFA also increases vascular permeability by altering endothelial junctions, contributing to fluid leakage in conditions such as inflammation and tumors Targeted therapies, such as bevacizumab and other anti-VEGF agents, inhibit VEGFA activity to suppress angiogenesis and tumor growth in various cancers and ocular diseases
Productos relacionados
Vascular Endothelial Growth Factor A (VEGFA) Antibody
VEGFA Antibody is a Rabbit Polyclonal antibody against VEGFA. This gene is a member of the PDGF/VEGF growth factor famil…
Ver producto
Vascular Endothelial Growth Factor A (VEGFA) Antibody
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide lin…
Ver producto
Vascular Endothelial Growth Factor A (VEGFA) Antibody
VEGFA is a member of the PDGF/VEGF growth factor family and and is often found as a disulfide linked homodimer. This pro…
Ver producto