USP44 antibody

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Description
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | ubiquitin specific peptidase 44 (USP44) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 1:500-1:5000 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 81 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | Q9H0E7 |
Gene ID | 84101 |
Alias | Ubiquitin carboxyl-terminal hydrolase 44,Deubiquitinating enzyme 44,Ubiquitin thioesterase 44,Ubiquitin-specific-processing protease 44,USP44 |
Background | Antibody anti-USP44 |
Status | RUO |
Note | Mol. Weight 81 kDa |
Descripción
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