USP44 antibody

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935106861
info@markelab.com
name
USP44 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09334
tested applications
ELISA, WB

Description

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
ubiquitin specific peptidase 44 (USP44)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:500-1:5000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
81 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9H0E7
Gene ID
84101
Alias
Ubiquitin carboxyl-terminal hydrolase 44,Deubiquitinating enzyme 44,Ubiquitin thioesterase 44,Ubiquitin-specific-processing protease 44,USP44
Background
Antibody anti-USP44
Status
RUO
Note
Mol. Weight 81 kDa

Descripción

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