USP21 antibody
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Description
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di-and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination(By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates(PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization(PubMed:26100909).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ubiquitin specific peptidase 21 (USP21) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 63 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UK80 |
| Gene ID | 27005 |
| Alias | Ubiquitin carboxyl-terminal hydrolase 21,Deubiquitinating enzyme 21,Ubiquitin thioesterase 21,Ubiquitin-specific-processing protease 21,USP21,USP23 |
| Background | Antibody anti-USP21 |
| Status | RUO |
| Note | Mol. Weight 63 kDa |
Descripción
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