UPF3B antibody
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Description
Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UPF3 regulator of nonsense transcripts homolog B(yeast) (UPF3B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC:1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 58 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BZI7 |
| Gene ID | 65109 |
| Alias | Regulator of nonsense transcripts 3B,Nonsense mRNA reducing factor 3B,Up-frameshift suppressor 3 homolog B (hUpf3B),Up-frameshift suppressor 3 homolog on chromosome X (hUpf3p-X),UPF3B,RENT3B,UPF3X |
| Background | Antibody anti-UPF3B |
| Status | RUO |
| Note | Mol. Weight 58 kDa |
Descripción
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