UPF1 antibody
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Description
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 124 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92900 |
| Gene ID | 5976 |
| Alias | Regulator of nonsense transcripts 1,ATP-dependent helicase RENT1,Nonsense mRNA reducing factor 1 (NORF1),Up-frameshift suppressor 1 homolog (hUpf1),UPF1,KIAA0221,RENT1 |
| Background | Antibody anti-UPF1 |
| Status | RUO |
| Note | Mol. Weight 124 kDa |
Descripción
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