anti- uPAR antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | plasminogen activator, urokinase receptor |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37-70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q03405 |
| Alias | CD87, MO3, PLAUR, U PAR, UPAR, URKR |
| Background | Antibody anti-uPAR |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Related Products
anti- uPAR antibody
Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)
Ver Producto
Human Plasminogen Activator, Urokinase Receptor (uPAR) Protein
Human Plasminogen Activator, Urokinase Receptor (uPAR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto
Mouse Plasminogen Activator, Urokinase Receptor (uPAR) Protein
Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Ver Producto