UBE2K antibody
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Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation(ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ubiquitin-conjugating enzyme E2K (UBE2K) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 25 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P61086 |
| Gene ID | 3093 |
| Alias | Ubiquitin-conjugating enzyme E2 K,E2 ubiquitin-conjugating enzyme K,Huntingtin-interacting protein 2 (HIP-2),Ubiquitin carrier protein,Ubiquitin-conjugating enzyme E2-25 kDa (Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K),Ubiquitin-protein ligase,UBE2K,HIP2,LIG |
| Background | Antibody anti-UBE2K |
| Status | RUO |
| Note | Mol. Weight 25 kDa |
Descripción
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UBE2K antibody
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