U2AF1 antibody
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Description
U2 auxiliary factor(U2AF), comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2(RNU2) small nuclear RNA auxiliary factor 1(U2AF1,synonyms: RN, FP793, U2AF35, U2AFBP, RNU2AF1)is the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. The U2AF1 gene is localized to chromosome 21q22.3, which is the critical region for three diseases, progressive myoclonus epilepsy, autoimmune polyglandular disease type 1, and one form of bipolar affective disorder.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | U2 small nuclear RNA auxiliary factor 1 (U2AF1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 1E9 |
| Observed MW | 38 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q01081 |
| Gene ID | 7307 |
| Alias | Splicing factor U2AF 35 kDa subunit,U2 auxiliary factor 35 kDa subunit,U2 small nuclear RNA auxiliary factor 1,U2 snRNP auxiliary factor small subunit,U2AF1,U2AF35,U2AFBP |
| Background | Antibody anti-U2AF1 |
| Status | RUO |
| Note | Mol. Weight 38 kDa |
Descripción
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U2AF1 antibody
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ver ProductoU2AF1 antibody
U2 auxiliary factor(U2AF), comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2(RNU2) small nuclear RNA auxiliary factor 1(U2AF1,synonyms: RN, FP793, U2AF35, U2AFBP, RNU2AF1)is the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. The U2AF1 gene is localized to chromosome 21q22.3, which is the critical region for three diseases, progressive myoclonus epilepsy, autoimmune polyglandular disease type 1, and one form of bipolar affective disorder.
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