TNKS antibody
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Description
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation(PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 150 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95271 |
| Gene ID | 8658 |
| Alias | Poly [ADP-ribose] polymerase tankyrase-1,ADP-ribosyltransferase diphtheria toxin-like 5 (ARTD5),Poly [ADP-ribose] polymerase 5A,Protein poly-ADP-ribosyltransferase tankyrase-1,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I,Tankyrase-1 (TANK1),TNKS,PARP5A,PARPL,TIN1,TINF1,TNKS1 |
| Background | Antibody anti-TNKS |
| Status | RUO |
| Note | Mol. Weight 150 kDa |
Descripción
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