TMED4 antibody
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935106861
info@markelab.com
name
TMED4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08740
tested applications
ELISA, IF, WB
Description
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | transmembrane emp24 protein transport domain containing 4 (TMED4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 26 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IF, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q7Z7H5 |
| Gene ID | 222068 |
| Alias | ERS25, GMP25iso, HNLF, p24a3, p24alpha3,Putative NF-kappa-B-activating protein 156,p24 family protein alpha-3,p24alpha3 |
| Background | Antibody anti-TMED4 |
| Status | RUO |
| Note | Mol. Weight 26 kDa |
Descripción
TMED4, a key p24 family member, participates in the regulation of vesicle-mediated trafficking in the early secretory pathway, facilitating cargo transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. TMED4 interacts with coat proteins (COPII and COPI) to enable vesicle budding, cargo sorting, and retrieval, ensuring protein quality control and proper trafficking dynamics. It also contributes to maintaining Golgi organization, regulating secretory pathway efficiency, and supporting protein maturation processes. TMED4 is widely expressed across various tissues, particularly in actively secreting cells, where it supports cellular homeostasis and organelle function. Dysregulation of TMED4 is associated with neurodegeneration, metabolic disorders, and cancers, where altered trafficking pathways lead to protein mislocalization and cellular stress. Knockdown studies reveal disrupted vesicle formation, increased ER stress, and impaired protein transport, underscoring its role in coordinating intracellular trafficking, protein stability, and cellular function.
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