TGFB2-Specific antibody
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935106861
info@markelab.com
name
TGFB2-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08639
tested applications
ELISA, WB, IHC, IF
Description
Tranforming growth factor beta-2(TGFB2), also named G-TSF, BSC-1 cell growth inhibitor, Polyergin and Cetermin, belongs to the TGF-beta family. TGFB2 is a secreted protein and contains a 19aa signal peptides at its N-terminal. Heterodimers with TGFB1 and with TGFB2 have been found in bone. It was proved to have suppressive effects on interleukin-2 dependent T-cell growth. This antibody is TGFB2 specific not detecting other TGFBs.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | transforming growth factor, beta 2 (TGFB2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 44 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P61812 |
| Gene ID | 7042 |
| Alias | G-TSF,LDS4,TGF-beta2,Cetermin,Glioblastoma-derived T-cell suppressor factor |
| Background | Antibody anti-TGFB2 |
| Status | RUO |
| Note | Mol. Weight 44 kDa |
Descripción
TGFB2 is a member of the TGF-β cytokine family, which regulates a wide range of cellular processes, including proliferation, differentiation, migration, apoptosis, and immune suppression. TGFB2 is critically involved in embryogenesis, particularly in the development of the heart, lungs, and central nervous system, as well as in tissue homeostasis and repair. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression and cellular responses to environmental stimuli. TGFB2 plays an essential role in immune regulation, where it suppresses inflammation and promotes tolerance by inducing regulatory T cell (Treg) development. Dysregulation of TGFB2 is implicated in developmental disorders, fibrosis, and tumor progression, where it drives epithelial-mesenchymal transition (EMT) and facilitates immune evasion. Knockout studies show severe developmental defects, including cardiac abnormalities, craniofacial malformations, and impaired organogenesis, underscoring TGFB2’s importance in tissue development, immune modulation, and homeostatic maintenance.
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