TFEC antibody

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Description
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F(that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase(TRAP) E-box containing promoter(By similarity). Collaborates with MITF in target gene activation(By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence(By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer(By similarity). Binds DNA in a homo-or heterodimeric form.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | transcription factor EC (TFEC) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 65 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB, IHC, IP |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | O14948 |
Gene ID | 22797 |
Alias | Transcription factor EC (TFE-C),Class E basic helix-loop-helix protein 34 (bHLHe34),Transcription factor EC-like (hTFEC-L),TFEC,BHLHE34,TCFEC,TFECL |
Background | Antibody anti-TFEC |
Status | RUO |
Note | Mol. Weight 65 kDa |
Descripción
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Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F(that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase(TRAP) E-box containing promoter(By similarity). Collaborates with MITF in target gene activation(By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence(By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer(By similarity). Binds DNA in a homo-or heterodimeric form.
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