STK24 antibody
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Description
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38(MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | serine/threonine kinase 24(STE20 homolog, yeast) (STK24) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 52 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y6E0 |
| Gene ID | 8428 |
| Alias | Serine/threonine-protein kinase 24,Mammalian STE20-like protein kinase 3 (MST-3),STE20-like kinase MST3,Serine/threonine-protein kinase 24 36 kDa subunit Alternative names: Mammalian STE20-like protein kinase 3 N-terminal (MST3/N),Serine/threonine-protein kinase 24 12 kDa subunit Alternative names: Mammalian STE20-like protein kinase 3 C-terminal (MST3/C),STK24,MST3,STK3 |
| Background | Antibody anti-STK24 |
| Status | RUO |
| Note | Mol. Weight 52 kDa |
Descripción
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