STAM2 antibody
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Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body(MVBs) when complexed with HGS(ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | signal transducing adaptor molecule(SH3 domain and ITAM motif) 2 (STAM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 68 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O75886 |
| Gene ID | 10254 |
| Alias | Signal transducing adapter molecule 2 (STAM-2),Hrs-binding protein,STAM2,HBP |
| Background | Antibody anti-STAM2 |
| Status | RUO |
| Note | Mol. Weight 68 kDa |
Descripción
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