SPO11 antibody
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Description
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks(DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SPO11 meiotic protein covalently bound to DSB homolog (SPO11) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55-70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y5K1 |
| Gene ID | 23626 |
| Alias | Meiotic recombination protein SPO11,Cancer/testis antigen 35 (CT35),SPO11 |
| Background | Antibody anti-SPO11 |
| Status | RUO |
| Note | Mol. Weight 55-70 kDa |
Descripción
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