SOCS6 antibody
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Name
SOCS6 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab08102
Tested Applications
ELISA, WB, IHC
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins(By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | suppressor of cytokine signaling 6 (SOCS6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O14544 |
| Gene ID | 9306 |
| Alias | SOSC6,CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4 |
| Background | Antibody anti-SOCS6 |
| Status | RUO |
| Note | Mol. Weight 70 kDa |
Background
SOCS6 is a member of the SOCS protein family that regulates cytokine and growth factor signaling pathways, particularly those mediated by insulin and receptor tyrosine kinases (RTKs). It inhibits signaling by targeting receptor complexes and signaling intermediates for ubiquitin-mediated degradation via its SOCS box domain, thus fine-tuning pathways such as the PI3K/Akt and MAPK cascades. SOCS6 is broadly expressed in tissues like the liver, pancreas, and skeletal muscle, where it regulates processes like cell growth, glucose metabolism, and insulin sensitivity. It has a role in tumor suppression by inhibiting growth factor signaling and promoting apoptosis in cancer cells. Dysregulation of SOCS6 is linked to metabolic disorders, including insulin resistance and diabetes, as well as cancer progression due to impaired signaling control. Knockdown studies reveal enhanced RTK activity, increased cellular proliferation, and reduced apoptosis, highlighting its role as a regulator of metabolic signaling, growth, and tumor suppression.
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