SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins(By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Primary Antibodies
polyclonal
human,mouse,rat
suppressor of cytokine signaling 6
Rabbit
IgG
Unconjugated
liquid
ELISA, WB, IHC
70 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:2000; IHC: 1:20-1:200
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
SOCS6
SOSC6,CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4
This product is for research use only.
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May ...
Precio a consultar
Ver másThe protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokin...
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