SMURF1 antibody
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Description
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes(PubMed:23999003).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 83-90 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HCE7 |
| Gene ID | 57154 |
| Alias | E3 ubiquitin-protein ligase SMURF1 (hSMURF1),HECT-type E3 ubiquitin transferase SMURF1,SMAD ubiquitination regulatory factor 1,SMAD-specific E3 ubiquitin-protein ligase 1,SMURF1,KIAA1625 |
| Background | Antibody anti-SMURF1 |
| Status | RUO |
| Note | Mol. Weight 83-90 kDa |
Descripción
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