SLC12A5-Specific antibody
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935106861
info@markelab.com
name
SLC12A5-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07908
tested applications
ELISA, WB, IHC
Description
KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl-cotransporter that is essential for Cl-homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | solute carrier family 12(potassium-chloride transporter), member 5 (SLC12A5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 126 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H2X9 |
| Alias | Solute carrier family 12 member 5,Electroneutral potassium-chloride cotransporter 2,K-Cl cotransporter 2 (hKCC2),Neuronal K-Cl cotransporter,SLC12A5,KCC2,KIAA1176 |
| Background | Antibody anti-SLC12A5 |
| Status | RUO |
| Note | Mol. Weight 126 kDa |
Descripción
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KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl-cotransporter that is essential for Cl-homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.
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