anti- SH2D5 antibody
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935106861
info@markelab.com
name
anti- SH2D5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07825
tested applications
ELISA, IF, WB
Description
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 domain containing 5 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43-47 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IF, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6ZV89 |
| Gene ID | 400745 |
| Alias | SH2D5 |
| Background | Antibody anti-SH2D5 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
SH2 domain-containing 5 (SH2D5) is a member of the SH2 domain-containing protein family, typically involved in intracellular signaling and protein-protein interactions through recognition of phosphorylated tyrosine residues. While the specific functions of SH2D5 remain under investigation, it is thought to play a role in neuronal development and synaptic signaling due to its expression patterns in brain tissues and its potential interactions with signaling molecules regulating neural pathways. SH2D5 may participate in pathways that influence cytoskeletal organization, cell migration, and differentiation, as it is linked to processes involving actin remodeling and adhesion dynamics. Recent studies suggest its involvement in modulating signal transduction cascades critical for maintaining cellular homeostasis and response to extracellular stimuli. Dysregulation or mutations in SH2D5 have been associated with neurological disorders, including autism spectrum disorders and intellectual disabilities, indicating its importance in brain function. Furthermore, SH2D5 might influence immune cell signaling, given the role of SH2 domain-containing proteins in immune regulation, although its specific contributions to immune system processes are not yet fully defined. Ongoing research aims to delineate its interaction partners and signaling networks to better understand its physiological and pathological roles.
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