anti- SASH1 antibody

Product specifications

Primary Antibodies

SAM and SH3 domain-containing protein 1

Rabbit

human,mouse

WB: 1:500-1:2000

polyclonal

Unconjugated

IgG

170kDa

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA, WB

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

O94885

23328

CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein

Antibody anti-SASH1

RUO

This product is for research use only.

SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases

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