SASH1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
SASH1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab10529
Tested Applications
ELISA, WB
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | SAM and SH3 domain-containing protein 1 (SASH1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 170kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94885 |
| Gene ID | 23328 |
| Alias | CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein |
| Background | Antibody anti-SASH1 |
| Status | RUO |
| Note | Mol. Weight 170 kDa |
Background
SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases
Productos relacionados
SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
SASH1 may have a role in a signaling pathway and could act as a tumor suppressor.…
Ver producto
Mouse Sash1 Antibody
Sash1 may have a role in a signaling pathway. Could act as a tumor suppressor.…
Ver producto
SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
SASH1 Antibody is a Rabbit Polyclonal against SASH1.…
Ver producto