S1PR5 antibody

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
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935106861
info@markelab.com
name
S1PR5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07570
tested applications
ELISA, WB

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
sphingosine-1-phosphate receptor 5 (S1PR5)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:1000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
50-55 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9H228
Gene ID
53637
Alias
S1PR5,EDG8,Edg-8,S1P5,SPPR-1,SPPR-2,endothelial differentiation G protein-coupled receptor 8,nerve growth factor-regulated G-protein-coupled receptor 1
Background
Antibody anti-S1PR5
Status
RUO
Note
Mol. Weight 50-55 kDa

S1PR5 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), predominantly expressed in oligodendrocytes, natural killer (NK) cells, and endothelial cells. S1PR5 couples to Gi and G12/13 proteins, regulating pathways involved in cell migration, proliferation, and survival. In the central nervous system, S1PR5 plays a critical role in oligodendrocyte differentiation and myelination, contributing to neuronal protection and repair. It also regulates NK cell trafficking and activity, enhancing immune surveillance and anti-tumor responses. Dysregulation of S1PR5 signaling is implicated in neurodegenerative diseases, such as multiple sclerosis, where impaired myelination contributes to disease pathology. In cancer, S1PR5 expression is linked to immune evasion and tumor progression, particularly through modulation of NK cell function. S1PR5 agonists are being developed as therapies for multiple sclerosis to promote remyelination and reduce neuroinflammation, while its role in immune cell regulation makes it a promising target for cancer immunotherapy and inflammatory diseases.

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