RPGR antibody
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Description
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes(By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | retinitis pigmentosa GTPase regulator (RPGR) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 113 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92834 |
| Gene ID | 6103 |
| Alias | X-linked retinitis pigmentosa GTPase regulator,RPGR,RP3,XLRP3 |
| Background | Antibody anti-RPGR |
| Status | RUO |
| Note | Mol. Weight 113 kDa |
Descripción
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RPGR antibody
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes(By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.
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X-Linked Retinitis Pigmentosa GTPase Regulator (RPGR) Antibody
RPGR Antibody is a Rabbit Polyclonal antibody against RPGR. This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008].
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