RPE65 antibody
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Description
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A(all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH(isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | retinal pigment epithelium-specific protein 65kDa (RPE65) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65kd,61kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q16518 |
| Gene ID | 6121 |
| Alias | Retinoid isomerohydrolase,All-trans-retinyl-palmitate hydrolase,Lutein isomerase,Meso-zeaxanthin isomerase,Retinal pigment epithelium-specific 65 kDa protein,Retinol isomerase,RPE65 |
| Background | Antibody anti-RPE65 |
| Status | RUO |
| Note | Mol. Weight 65 kDa, 61 kDa |
Descripción
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