RBBP8 antibody
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Description
Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | retinoblastoma binding protein 8 (RBBP8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q99708 |
| Gene ID | 5932 |
| Alias | DNA endonuclease RBBP8,CtBP-interacting protein (CtIP),Retinoblastoma-binding protein 8 (RBBP-8),Retinoblastoma-interacting protein and myosin-like (RIM),Sporulation in the absence of SPO11 protein 2 homolog (SAE2),RBBP8,CTIP |
| Background | Antibody anti-RBBP8 |
| Status | RUO |
| Note | Mol. Weight 120 kDa |
Descripción
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