RBBP6 antibody
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Description
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome(PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth(By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites(CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | retinoblastoma binding protein 6 (RBBP6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 200 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q7Z6E9 |
| Gene ID | 5930 |
| Alias | E3 ubiquitin-protein ligase RBBP6,Proliferation potential-related protein,Protein P2P-R,RING-type E3 ubiquitin transferase RBBP6,Retinoblastoma-binding Q protein 1 (RBQ-1),Retinoblastoma-binding protein 6,p53-associated cellular protein of testis,RBBP6,P2PR,PACT,RBQ1 |
| Background | Antibody anti-RBBP6 |
| Status | RUO |
| Note | Mol. Weight 200 kDa |
Descripción
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