RAB40B antibody
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935106861
info@markelab.com
name
RAB40B antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07034
tested applications
ELISA, IHC, WB
Description
May be a substrate-recognition component of a SCF-like ECS(Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB40B, member RAS oncogene family (RAB40B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 56 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q12829 |
| Gene ID | 10966 |
| Alias | RAR,SEC4L,SOCS box-containing protein RAR,Protein Rar,Ras-related protein Rab-40B |
| Background | Antibody anti-RAB40B |
| Status | RUO |
| Note | Mol. Weight 56 kDa |
Descripción
RAB40B, member RAS oncogene family (RAB40B) is another member of the RAB GTPase family and shares many functions with other RAB proteins in regulating vesicular trafficking within the cell. RAB40B specifically aids in the sorting and transport of vesicles, ensuring that cellular components are directed to their proper locations, including the recycling of proteins and lipids between compartments. This regulation is vital for maintaining cellular processes such as signal transduction, protein synthesis, and receptor recycling. RAB40B is particularly involved in regulating the trafficking of specific cargo between the endosomes, lysosomes, and the plasma membrane, which ensures the proper processing of membrane-bound proteins. Furthermore, RAB40B contributes to cellular processes like endocytosis, where external signals and molecules are internalized by the cell for further processing. Disruptions in RAB40B’s function have been implicated in cancer, where abnormal vesicular trafficking and receptor signaling contribute to tumorigenesis. Its role in cellular trafficking also connects RAB40B to neurodegenerative diseases, where impaired vesicular recycling and dysfunction in autophagy lead to the accumulation of damaged proteins, contributing to neuronal degeneration.
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