RAB38 antibody
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Description
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7(By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis(PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis(PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB38, member RAS oncogene family (RAB38) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 25 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P57729 |
| Gene ID | 23682 |
| Alias | rrGTPbp,NY-MEL-1,Melanoma antigen NY-MEL-1,Ras-related protein Rab-38 |
| Background | Antibody anti-RAB38 |
| Status | RUO |
| Note | Mol. Weight 25 kDa |
Descripción
RAB38, member RAS oncogene family (RAB38) is involved in regulating vesicular trafficking, with a primary focus on the sorting and delivery of cargo proteins within the secretory pathway It plays a key role in the movement of vesicles from the Golgi apparatus to other cellular compartments such as the plasma membrane or lysosomes, which are essential for proper cell function and membrane recycling RAB38 is involved in the maintenance of cell signaling by regulating the trafficking of receptor proteins and enzymes, ensuring their correct localization and function Additionally, RAB38 participates in autophagy, a critical cellular process for degrading and recycling cellular components RAB38’s dysfunction is associated with disorders related to impaired vesicular trafficking, including certain types of cancer and neurodegenerative diseases where disturbed cellular function contributes to pathological changes
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May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7(By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis(PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis(PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes(By similarity).
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