The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum(ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Primary Antibodies
polyclonal
human,mouse,rat
RAB1A, member RAS oncogene family
Rabbit
IgG
Unconjugated
liquid
ELISA, IHC, WB
23 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:2000; IHC: 1:20-1:200
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
RAB1A
RAB1,YPT1,Ras-related protein Rab-1A,YPT1-related protein
This product is for research use only.
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles...
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Ver másRabbit Polyclonal against the RAB1A protein.
337.5€ (100 µg)
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