RAB17 antibody
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935106861
info@markelab.com
name
RAB17 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06997
tested applications
ELISA, WB, IHC
Description
The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB17, member RAS oncogene family (RAB17) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 23 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H0T7 |
| Gene ID | 64284 |
| Alias | Ras-related protein Rab-17 |
| Background | Antibody anti-RAB17 |
| Status | RUO |
| Note | Mol. Weight 23 kDa |
Descripción
RAB17, member RAS oncogene family (RAB17) is involved in regulating vesicle trafficking between various cellular compartments, including the Golgi apparatus, endosomes, and the plasma membrane RAB17 is important for maintaining the recycling of membrane proteins and internalized receptors, ensuring proper cellular signaling and the recycling of molecules involved in cell surface receptor activity It has been implicated in controlling membrane dynamics, particularly in processes related to vesicle formation, membrane fusion, and cell polarity RAB17 also plays a role in regulating actin dynamics, which is essential for cell motility and tissue remodeling, particularly in epithelial cells where proper adhesion and junction formation are critical Its dysfunction is linked to a variety of diseases, including cancer, where dysregulated vesicular trafficking may promote metastasis by enhancing cell migration and altering receptor activity Additionally, RAB17 is involved in the immune response by regulating the trafficking of immune receptors, impacting inflammation and cell communication during immune activation
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