PTGDS antibody

Este producto es parte de PTGDS - Prostaglandin D2 Synthase
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935106861
info@markelab.com
name
PTGDS antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06914
tested applications
ELISA, WB, IHC

Description

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
prostaglandin D2 synthase 21kDa (brain) (PTGDS)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
33 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
UniProt ID
P41222
Gene ID
5730
Alias
L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2,Beta-trace protein,Glutathione-independent PGD synthase
Background
Antibody anti-PTGDS
Status
RUO
Note
Mol. Weight 21-28 kDa

Descripción

Prostaglandin D2 Synthase (PTGDS) is an enzyme that catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a key lipid mediator involved in sleep regulation, allergic inflammation, vasodilation, and immune modulation PTGDS is highly expressed in the brain, heart, and male reproductive organs, where it participates in cerebrospinal fluid production, detoxification of free radicals, and maintenance of male fertility PGD2 plays a central role in allergic reactions, mediating bronchoconstriction in asthma and inflammation in rhinitis Dysregulation of PTGDS contributes to neurological disorders such as Alzheimer’s disease by facilitating tau phosphorylation, amyloid deposition, and oxidative stress PTGDS also serves as a biomarker for cardiovascular disease, brain injury, and central nervous system inflammation Its role in lipid signaling and antioxidant defense highlights its importance in both homeostasis and disease progression

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