PSME4 antibody
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Description
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP-and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like(BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | proteasome(prosome, macropain) activator subunit 4 (PSME4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:1000 ; IHC: 1:50-1:500; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 140 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14997 |
| Gene ID | 23198 |
| Alias | Proteasome activator complex subunit 4,Proteasome activator PA200,PSME4,KIAA0077 |
| Background | Antibody anti-PSME4 |
| Status | RUO |
| Note | Mol. Weight 140 kDa |
Descripción
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