PQBP1 antibody
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Description
Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species(PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | polyglutamine binding protein 1 (PQBP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38 kDa, 30 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O60828 |
| Gene ID | 10084 |
| Alias | Polyglutamine-binding protein 1 (PQBP-1),38 kDa nuclear protein containing a WW domain (Npw38),Polyglutamine tract-binding protein 1,PQBP1,NPW38 |
| Background | Antibody anti-PQBP1 |
| Status | RUO |
| Note | Mol. Weight 38 kDa, 30 kDa |
Descripción
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