POLR3K antibody
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Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | polymerase(RNA) III(DNA directed) polypeptide K, 12.3 kDa (POLR3K) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 12 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IF, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y2Y1 |
| Gene ID | 51728 |
| Alias | DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10),DNA-directed RNA polymerase III subunit K,RNA polymerase III 12.5 kDa subunit (RPC12.5),RNA polymerase III subunit C11 (HsC11p, RPC11, hRPC11),POLR3K,RPC11 |
| Background | Antibody anti-POLR3K |
| Status | RUO |
| Note | Mol. Weight 12 kDa |
Descripción
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