POLR1A antibody
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Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | polymerase(RNA) I polypeptide A, 194kDa (POLR1A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 190-195 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95602 |
| Gene ID | 25885 |
| Alias | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1),A190,DNA-directed RNA polymerase I largest subunit,DNA-directed RNA polymerase I subunit A,RNA polymerase I 194 kDa subunit (RPA194),POLR1A |
| Background | Antibody anti-POLR1A |
| Status | RUO |
| Note | Mol. Weight 190-195 kDa |
Descripción
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