PHF6 antibody
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935106861
info@markelab.com
name
PHF6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06388
tested applications
ELISA, WB, IHC
Description
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA(rRNA) transcription.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 6 (PHF6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 41 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IWS0 |
| Gene ID | 84295 |
| Alias | PHF6,CENP-31,KIAA1823,PHD-like zinc finger protein |
| Background | Antibody anti-PHF6 |
| Status | RUO |
| Note | Mol. Weight 41 kDa |
Descripción
PHF6 is a PHD finger domain-containing protein that functions in transcriptional regulation, chromatin remodeling, and cell cycle control. It interacts with components of chromatin-modifying complexes to facilitate gene silencing or activation, depending on cellular context. PHF6 is expressed in neural and hematopoietic tissues, where it regulates processes such as neurodevelopment, cell proliferation, and differentiation. Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome, a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and craniofacial abnormalities. PHF6 is also implicated in hematological cancers, including T-cell leukemia, where its loss of function disrupts chromatin organization and transcriptional regulation. Knockout studies demonstrate defects in neuronal development, impaired cell cycle progression, and increased genomic instability, highlighting its essential role in chromatin regulation, neurodevelopment, and disease pathogenesis.
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