PHF5A antibody
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935106861
info@markelab.com
name
PHF5A antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06387
tested applications
ELISA, WB, IP
Description
Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha. Also involved in pre-mRNA splicing.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 5A (PHF5A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 12-14 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q7RTV0 |
| Gene ID | 84844 |
| Alias | NI, Rds3, SAP14b, SF3B7, SF3b14b, bK223H9.2,PHD finger-like domain protein 5A |
| Background | Antibody anti-PHF5A |
| Status | RUO |
| Note | Mol. Weight 12-14 kDa |
Descripción
PHF5A is a chromatin-binding protein that interacts with histones through its PHD finger domain and serves as a core component of the spliceosome complex. It regulates alternative splicing of pre-mRNA, controlling the expression of genes involved in cell cycle progression, differentiation, and apoptosis. PHF5A is essential for the recognition of splice sites and the recruitment of splicing machinery during transcription. It is ubiquitously expressed in proliferating tissues, particularly in stem cells and cancer cells, where it maintains proper gene expression programs. Dysregulation of PHF5A has been implicated in cancer, including glioblastoma and leukemia, where it promotes tumor progression by modulating splicing events that regulate survival and proliferation. Knockdown studies reveal impaired splicing, reduced cell proliferation, and increased apoptosis, underscoring its role as a critical regulator of RNA processing, transcription, and cellular growth.
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